Week 17 closes out with a blockbuster matchup as the Bills travel to the Bengals. Can Buffalo take another step towards the top seed in the AFC?

Will the Titans put up any fight when they host the Cowboys in tonight's Thursday Night Football?

The Jaguars travel to New York to take on the Jets in what is a must win game for both teams to keep their playoff hopes alive. Which 2nd year QB will lead their team to the win?

Two of the best teams in the league last season meet tonight with the Rams heading to Green Bay. Can the Rams ensure that Green Bay's season ends as miserably as theirs?

Mr Irrelevant Brock Purdy and the 49ers head to Seattle to take on the Seahawks tonight. Can they seal the NFC West or will Geno Smith cause an upset?

Can Kyler Murray and the Cardinals upset the Patriots when they face each other in tonight's Monday Night Football?

The Raiders are in LA to take on the Rams in tonight's Thursday Night Football. Will we see new signing Baker Mayfield on the field for the Rams? Does it matter?

The Saints are heading to Tampa Bay tonight in the final game of week 13. Can they keep their season alive or will the Bucs extend their lead at the top of the NFC South?

It's a big AFC East clash tonight with the Bills travelling to the Patriots. Can the Patriots cause the upset to keep themselves in playoff contention?

The Steelers travel to Indianapolis to take on the Colts in this week's Monday Night Football. Can rookie Kenny Pickett lead his team to the win over veteran Matt Ryan?